Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide

Title:
Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide
Creator:
Heidelberger, Michael
Mond, J. J.
Thorbecke, G. J.
Lerman, S. P.
Romano, T. J.
Date:
February 1975
Description:
Heidelberger continued his detailed chemical studies of polysaccharide antigens after he returned to New York City and joined the Department of Pathology at the New York University School of Medicine as adjunct professor in 1964. In this article, Heidelberger and his coauthors examined the immunological effects of haptens, small molecules that are not antigenic by themselves but that can elicit the formation of antibodies of appropriate specificity and react with such antibodies when chemically fused, or conjugated, to a larger antigenic molecule, here pneumococcal polysaccharide. In particular, the article compared the effects of conjugated haptens on the primary antibody response--the initial immune response to an antigen--with their effects on the secondary antibody response, in which the level of immunity acquired during the first response (immunity that persists for a variable period of time) normally is boosted by renewed exposure to the same antigenic agent.. Haptens were given their name (from the Greek haptein, to fasten) and their role in immunology was first studied by Karl Landsteiner, with whom Heidelberger collaborated during the early 1920s at the Rockefeller Institute.
Periodical:
Cellular Immunology
Publisher:
The Academic Press
Rights:
Reprinted from Cellular Immunology, Vol. 15, Lerman, S. P., T. J. Romano, J. J. Mond, Michael Heidelberger, and G. J. Thorbecke, "Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide," pp. 321-325, Copyright 1975 with permission from Elsevier. and http://www.sciencedirect.com/
Genre:
Articles
Subject:
Antibodies, Haptens, and Polysaccharides
Format:
Text
Extent:
15 pages
Language:
English
Legacy Source Citation:
Periodical. Lerman, S. P., T. J. Romano, J. J. Mond, Michael Heidelberger, and G. J. Thorbecke. "Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide." Cellular Immunology 15, 2 (February 1975): 321-335. Article. 15 Images.. Cellular Immunology
Legacy ID:
DHBBKW
NLM ID:
101584940X160
Profiles Collection:
The Michael Heidelberger Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584940X160
Story Section:
"If I Have a Few More Years to Work, I'm Going Ahead": An Active Retirement, 1954-1991