Title:

A Method for the Preparation of Crystalline Oxyhemoglobin

Creator:

Heidelberger, Michael

Date:

1 July 1922

Description:

In 1921, Heidelberger began to work with Donald D. Van Slyke at the Rockefeller Institute's hospital. Van Slyke had been working to understand the functioning of the kidneys, and more specifically the interaction between oxygen and hemoglobin. At this time, oxyhemoglobin (in which an oxygen molecule is attached to the heme component of the hemoglobin protein) could be produced synthetically in quantities too small to be useful, and also lacked much oxygen-carrying capability. Van Slyke and his team asked Heidelberger to address this problem. In this article, Heidelberger describes a method he developed that created greater yields of oxyhemoglobin with nearly all of its oxygen-carrying power intact.

Periodical:

Journal of Biological Chemistry

Publisher:

American Society for Biochemistry and Molecular Biology

Rights:

Public Domain

Genre:

Articles

Subject:

Hemoglobins

Format:

Text

Extent:

10 pages

Language:

English

Legacy Source Citation:

Periodical. Heidelberger, Michael. "A Method for the Preparation of Crystalline Oxyhemoglobin." Journal of Biological Chemistry 53, 1 (1 July 1922): 31-40. Article. 10 Images.. Journal of Biological Chemistry

Legacy ID:

DHBBBC

NLM ID:

101584940X2

Profiles Collection:

The Michael Heidelberger Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584940X2

Story Section:

The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927