Title:

Letter from Michael Heidelberger to Kai O. Pedersen

Creator:

Heidelberger, Michael

Recipient:

Pedersen, Kai O.

Date:

15 February 1935

Description:

Twice, in 1934 and 1936, Heidelberger received a John Simon Guggenheim Memorial Fellowship for a stay of six weeks at the University of Uppsala in Sweden, where he used the first ultracentrifuge, constructed by Theodor Svedberg and Kai O. Pedersen, to determine the molecular weight of various proteins, including antibodies in horse antipneumococcal sera. During his first visit, Heidelberger brought purified thyroglobulin, a protein secreted by the thyroid gland. In experiments completed by Pedersen after Heidelberger's departure and discussed by Heidelberger in this letter, the two found to their surprise that thyroglobulin was of high molecular weight.

Location:

Box: 5. Folder: 9

Rights:

Public Domain

Genre:

Letters (correspondence)

Subject:

Molecular Weight, Thyroglobulin, and Ultracentrifugation

Format:

Text

Extent:

3 pages

Language:

English

Legacy ID:

DHBBNV

NLM ID:

101584940X220

Profiles Collection:

The Michael Heidelberger Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584940X220

Story Section:

Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954