Title:

Velocity of Combination of Antibody with Specific Polysaccharides of Pneumococcus

Creator:

Heidelberger, Michael
Mayer, Manfred M.

Date:

1 May 1942

Description:

In the early 1940s, Heidelberger turned his attention to studying immunological cross-reactions between type III and type VIII pneumococcal polysaccharide antigens, respectively, and antibodies formed against the other type of pneumococcal antigen (meaning that type III pneumococcal antigen reacted with type VIII anti-pneumococcal antibody, and type VIII pneumococcal antigen with type VIII anti-pneumococcal antibody). Immunological cross reactions occur when antibodies formed against one antigen react with another antigen that shares identical or closely related binding sites, called immunological determinants, with the first antigen. From such cross reactions scientists can deduce important details about the chemical composition of antigens and antibodies. In this paper, Heidelberger and Manfred Mayer reported their findings regarding the speed with which such cross reactions occurred.

Periodical:

Journal of Biological Chemistry

Publisher:

American Society for Biochemistry and Molecular Biology

Rights:

Public Domain

Genre:

Articles

Subject:

Antibodies, Polysaccharides, and Pneumococcal Infections

Format:

Text

Extent:

8 pages

Language:

English

Legacy Source Citation:

Periodical. Mayer, Manfred M., and Michael Heidelberger. "Velocity of Combination of Antibody with Specific Polysaccharides of Pneumococcus." Journal of Biological Chemistry 143, 3 (1 May 1942): 567-574. Article. 8 Images.. Journal of Biological Chemistry

Legacy ID:

DHBBCL

NLM ID:

101584940X30

Profiles Collection:

The Michael Heidelberger Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584940X30

Story Section:

Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954