Title:

The Human Antibody Response to Simultaneous Injection of Six Specific Polysaccharides of Pneumococcus

Creator:

Heidelberger, Michael
Di Lapi, Marie M.
MacLeod, Colin M. (Colin Munro), 1909-1972

Date:

September 1948

Description:

During World War II, Heidelberger became involved in an effort by military physicians to develop a pneumonia vaccine, consisting of a combination of purified polysaccharides of four specific pneumococcal types, for the immunization of troops. For this article, Heidelberger and one of his wartime collaborators, Colin MacLeod, along with M. M. Di Lapi, studied how the body reacted if injected with more than four types of specific polysaccharides (a combination of four types were administered during the military field trial) at one time, namely with specific polysaccharides of the six most common types of pneumonia. The authors found that such a vaccine was as effective as one made of four pneumococcal polysaccharide antigens in stimulating an immune response.

Periodical:

Journal of Experimental Medicine

Publisher:

Rockefeller Institute for Medical Research

Rights:

Reproduced from the Journal of Experimental Medicine, 1948, 88, 369-372 by copyright permission of the Rockefeller University Press.

Genre:

Articles

Subject:

Polysaccharides and Antibodies

Format:

Text

Extent:

4 pages

Language:

English

Legacy Source Citation:

Periodical. Heidelberger, Michael, Colin M. MacLeod, and Marie M. Di Lapi. "The Human Antibody Response to Simultaneous Injection of Six Specific Polysaccharides of Pneumococcus." Journal of Experimental Medicine 88, 3 (September 1948): 369-372. Article. 4 Images.. Journal of Experimental Medicine

Legacy ID:

DHBBCQ

NLM ID:

101584940X34

Profiles Collection:

The Michael Heidelberger Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584940X34

Story Section:

Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954