Immunological Relationships of Cell Constituents of Pneumococcus: Second Paper

Title:
Immunological Relationships of Cell Constituents of Pneumococcus: Second Paper
Creator:
Heidelberger, Michael
Avery, Oswald Theodore, 1877-1955
Date:
August 1925
Description:
In this article, Avery and Heidelberger discuss their findings regarding the immunologic relationship between the nucleoprotein and carbohydrate portions of pneumococcus. The pair found that the carbohydrate portion of each type of pneumococcus (by 1923 scientists had identified three different types I, II, and III, roughly based on capsule size) was in fact a polysaccharide unique to that particular type. They also found that while the nucleoprotein component is antigenic when isolated outside of the cell, the polysaccharide component is not. Heidelberger and Avery concluded that the two combine to form an antigenic complex that has different properties than each of its member components.
Periodical:
Journal of Experimental Medicine
Publisher:
Rockefeller Institute for Medical Research
Rights:
Reproduced from the Journal of Experimental Medicine, 1925, 42, 367-376 by copyright permission of the Rockefeller University Press.
Genre:
Articles
Subject:
Pneumococcal Infections and Streptococcus pneumoniae
Format:
Text
Extent:
10 pages
Language:
English
Legacy Source Citation:
Periodical. Avery, Oswald T., and Michael Heidelberger. "Immunological Relationships of Cell Constituents of Pneumococcus: Second Paper." Journal of Experimental Medicine 42, 3 (August 1925): 367-376. Article. 10 Images.. Journal of Experimental Medicine
Legacy ID:
DHBBBF
NLM ID:
101584940X4
Profiles Collection:
The Michael Heidelberger Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584940X4
Story Section:
The "Sugar-Coated Microbe" and the Search for a Cure for Pneumonia, 1919-1929