Brief Chronology

  • 1924 --Born in CaƱon City, Colorado (August 8)
  • 1943-46 --Engineering student in the Army Specialized Training Program
  • 1946, 1949 --Received BS and MD degrees from the University of Michigan
  • 1949-52 --Postdoctoral training in internal medicine at Peter Bent Brigham Hospital in Boston
  • 1950 --Married Dutch law student Henrietta Priscilla Dorothea Eekhof in the Hague, Netherlands
  • 1950-51 --James Jackson Cabot Research Fellow in Medicine, Harvard Medical School
  • 1952-53 --Research fellow in medicine at the Massachusetts General Hospital in Boston
  • 1953-55 --Clinical Associate, National Heart Institute, National Institutes of Health (NIH) in Bethesda, Maryland; investigated lipid transport in the blood
  • 1955-61 --Member of the senior research staff in the Laboratory of Cellular Metabolism, National Heart Institute
  • 1957 --Certified by the American Board of Internal Medicine
  • 1960 --First to describe and name Tangier disease, an abnormality in the storage of cholesterol in the body
  • 1960 --Published standard textbook, The Metabolic Basis of Inherited Disease, with John B. Stanbury and James B. Wyngaarden
  • 1961-66 --Clinical Director, National Heart Institute
  • 1962-66 --Head of the Section on Molecular Diseases in the Laboratory of Metabolism, National Heart Institute
  • 1966-68 --Director, National Heart Institute
  • 1967 -- New England Journal of Medicine published a five-part review of Fredrickson's work on abnormalities in lipid metabolism
  • 1968-74 --Scientific director, National Heart Institute
  • 1973 --Participants at the Gordon Conference on Nucleic Acids in New Hampshire called on their fellow scientists to voluntarily suspend certain experiments with recombinant DNA
  • 1974-75 --President of the Institute of Medicine of the National Academy of Sciences
  • 1975-81 --Director, National Institutes of Health
  • 1975 --Over 140 prominent molecular biologists and geneticists attending the Asilomar conference on the dangers of genetically reengineered microorganisms proposed a voluntary moratorium on recombinant DNA research until its scientific and ethical implications could be explored
  • 1975-78 --Chairman, Recombinant DNA Advisory Committee (RAC)
  • 1975-81 --Chairman, Interagency Committee on Recombinant DNA Research
  • 1976 --Released NIH Guidelines for Research Involving Recombinant DNA Molecules (June 23)
  • 1976 --Issued a draft Environmental Impact Statement for recombinant DNA experiments (September); a final statement was issued October 1977
  • 1977 --Initiated NIH Consensus Development Conferences to bridge scientific and professional differences among NIH personnel
  • 1978 --RAC expanded to include non-scientists, among them the new RAC chairman
  • 1978 --Chaired National Conference on Health Research Principles, held at NIH
  • 1978 --Established the Office of Medical Applications of Research at NIH
  • 1979 --Revised recombinant DNA guidelines took effect (January 2), easing containment requirements particularly for experiments involving Escherichia coli strain K-12 as a host-vector system
  • 1979 --In a time of federal budget shortfalls, Fredrickson secured funding for a minimum of 5,000 new NIH research grants
  • 1981-83 --Scholar-in-Residence, National Academy of Sciences
  • 1983-87 --Vice President, then President and CEO of the Howard Hughes Medical Institute, Chevy Chase, Maryland
  • 1987-2002 --Scholar at the National Library of Medicine, Bethesda
  • 1987-2002 --President, D.S. Fredrickson Associates, a health and science policy consulting firm
  • 2002 --Died at his home in Bethesda (June 7)