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This article marks the beginning of Rodbell's interest in cell receptors. In it, he related his discovery that fat cells could be isolated from other cells by treating them with preparations of collagenase, and also found that insulin could stimulate glucose uptake. This had far-reaching implications for the treatment of various diseases, as it was the first demonstration that insulin acted on individual cells.
Adenylyl Cyclases, Glucose, Hormones, and Metabolism
Format:
Text
Extent:
6 pages
Language:
English
Legacy Source Citation:
Periodical. Rodbell, Martin. "The Metabolism of Isolated Fat Cells: I. Effects of Hormones on Glucose Metabolism and Lipolysis." Journal of Biological Chemistry 239, 2 (February 1964): 375-380. Article. 6 Images.. Journal of Biological Chemistry