The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities


Title:
The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities
Description:
The second in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, he suggested that glucagon and inorganic fluoride activate the enzyme adenyl cyclase, an important component of some intracellular signaling pathways, by different mechanisms and possibly through different molecular entities, which indicated more than one mode of signal transduction.
Extent:
4 pages
Date Issued:
25 March 1971
Creator:
Birnbaumer, Lutz, Pohl, Stephen L., and Rodbell, Martin, 1925-1998
Source:
Periodical. Birnbaumer, Lutz, Stephen L. Pohl, and Martin Rodbell. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: II. Comparison Between Glucagon- and Fluoride-Stimulated Activities." Journal of Biological Chemistry 246, 6 (25 March 1971): 1857-1860. Article. 4 Images.. Journal of Biological Chemistry
Periodical:
Journal of Biological Chemistry
Publisher:
American Society for Biochemistry and Molecular Biology
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Subject:
Adenylyl Cyclases, Cell Membrane, Enzymes, Fluorides, Glucagon, and Pharmacology
Profiles in Science ID:
GGAAAX
NLM ID:
101584917X24
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 19. Folder: 10