The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity


Title:
The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity
Description:
The third in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In this article, Rodbell established that the glucagon receptor is involved in the activation of the enzyme adenyl cyclase and that intracellular signaling is achieved through specific GTP-binding heterotrimeric G-proteins.
Extent:
11 pages
Date Issued:
25 March 1971
Creator:
Rodbell, Martin, 1925-1998, Krans, Hendrik Michiel Jan, Pohl, Stephen L., and Birnbaumer, Lutz
Source:
Periodical. Rodbell, Martin, Hendrik Michiel Jan Krans, Stephen L. Pohl, and Lutz Birnbaumer. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: III. Binding of Glucagon: Method of Assay and Specificity." Journal of Biological Chemistry 246, 6 (25 March 1971): 1861-1871. Article. 11 Images.. Journal of Biological Chemistry
Periodical:
Journal of Biological Chemistry
Publisher:
American Society for Biochemistry and Molecular Biology
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Subject:
Adenylyl Cyclases, Binding Sites, Cell Membrane, Enzymes, Glucagon, and Pharmacology
Profiles in Science ID:
GGAAAY
NLM ID:
101584917X25
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 19. Folder: 10