The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon


Title:
The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon
Description:
The fourth in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In the last two articles of this series, Rodbell demonstrated that GTP affected the binding of glucagon to its receptors and was necessary for glucagon to activate adenyl cyclase, an important component of some intracellular signaling pathways.
Extent:
5 pages
Date Issued:
25 March 1971
Creator:
Rodbell, Martin, 1925-1998, Krans, Hendrik Michiel Jan, Pohl, Stephen L., and Birnbaumer, Lutz
Source:
Periodical. Rodbell, Martin, Hendrik Michiel Jan Krans, Stephen L. Pohl, and Lutz Birnbaumer. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: IV. Effects of Guanyl Nucleotides on Binding of 125 I-Glucagon." Journal of Biological Chemistry 246, 6 (25 March 1971): 1872-1876. Article. 5 Images.. Journal of Biological Chemistry
Periodical:
Journal of Biological Chemistry
Publisher:
American Society for Biochemistry and Molecular Biology
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Subject:
Adenylyl Cyclases, Binding Sites, Iodine Isotopes, Glucagon, Guanine Nucleotides, and Pharmacology
Profiles in Science ID:
GGAAAZ
NLM ID:
101584917X26
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 19. Folder: 10