The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action


Title:
The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action
Description:
The fifth in a now-classic series of five articles in which Rodbell concluded that GTP was likely the active biological factor in separating glucagon from the cell's receptor, which had important implications for the treatment of various disorders and diseases. In the last two articles of this series, Rodbell demonstrated that GTP affected the binding of glucagon to its receptors and was necessary for glucagon to activate adenyl cyclase, an important component of some intracellular signaling pathways.
Extent:
6 pages
Date Issued:
25 March 1971
Creator:
Rodbell, Martin, 1925-1998, Birnbaumer, Lutz, Pohl, Stephen L., and Krans, Hendrik Michiel Jan
Source:
Periodical. Rodbell, Martin, Lutz Birnbaumer, Stephen L. Pohl, and Hendrik Michiel Jan Krans. "The Glucagon-Sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver: V. An Obligatory Role of Guanyl Nucleotides in Glucagon Action." Journal of Biological Chemistry 246, 6 (25 March 1971): 1877-1882. Article. 6 Images.. Journal of Biological Chemistry
Periodical:
Journal of Biological Chemistry
Publisher:
American Society for Biochemistry and Molecular Biology
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Subject:
Adenylyl Cyclases, Binding Sites, Cell Membrane, and Guanine Nucleotides
Profiles in Science ID:
GGAABA
NLM ID:
101584917X27
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 19. Folder: 11