Title:

GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes

Creator:

Yamamura, Hiromi, 1961-
Lad, Pramod M.
Rodbell, Martin, 1925-1998

Date:

25 November 1977

Description:

The first of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane, the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular receptors were sophisticated enough to both inhibit and activate signal transduction.

Periodical:

Journal of Biological Chemistry

Publisher:

American Society for Biochemistry and Molecular Biology

Location:

Box: 19. Folder: 12

Rights:

Reproduced with permission of the American Society for Biochemistry and Molecular Biology.

Genre:

Articles

Subject:

Adenylyl Cyclases, Guanosine Triphosphate, Hormones, and Metabolism

Format:

Text

Extent:

3 pages

Relation:

Letter from Joshua Lederberg to Michael Doudoroff, 1948

Language:

English

Legacy Source Citation:

Periodical. Yamamura, Hirohei, Pramod M. Lad, and Martin Rodbell. "GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes." Journal of Biological Chemistry 252, 22 (25 November 1977): 7964-7966. Article. 3 Images.. Journal of Biological Chemistry

Legacy ID:

GGAABB

NLM ID:

101584917X28

Profiles Collection:

The Martin Rodbell Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584917X28

Story Section:

Signal Transduction and the Discovery of G-Proteins, 1969-1980