GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes


Title:
GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes
Creator:
Yamamura, Hiromi, 1961-
Lad, Pramod M.
Rodbell, Martin, 1925-1998
Date:
25 November 1977
Description:
The first of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane, the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular receptors were sophisticated enough to both inhibit and activate signal transduction.
Periodical:
Journal of Biological Chemistry
Publisher:
American Society for Biochemistry and Molecular Biology
Location:
Box: 19. Folder: 12
Rights:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Genre:
Articles
Subject:
Adenylyl Cyclases, Guanosine Triphosphate, Hormones, and Metabolism
Format:
Text
Extent:
3 pages
Relation:
Letter from Joshua Lederberg to Michael Doudoroff, 1948
Language:
English
Legacy Source Citation:
Periodical. Yamamura, Hirohei, Pramod M. Lad, and Martin Rodbell. "GTP Stimulates and Inhibits Adenylate Cyclase in Fat Cell Membranes through Distinct Regulatory Processes." Journal of Biological Chemistry 252, 22 (25 November 1977): 7964-7966. Article. 3 Images.. Journal of Biological Chemistry
Legacy ID:
GGAABB
NLM ID:
101584917X28
Profiles Collection:
The Martin Rodbell Papers
Story Section:
Signal Transduction and the Discovery of G-Proteins, 1969-1980