The Fat Cell Adenylate Cyclase System: Characterization and Manipulation of Its Biomodal Regulation by GTP


Title:
The Fat Cell Adenylate Cyclase System: Characterization and Manipulation of Its Biomodal Regulation by GTP
Creator:
Schlegel, Werner
Lin, Michael C.
Cooper, Dermot M.F.
Rodbell, Martin, 1925-1998
Date:
25 September 1979
Description:
The second of two articles in which Rodbell indicated that in addition to transducing hormone signals across the membrane, the G-protein could also inhibit signaling at the discriminator point. He provided evidence that G-proteins at the cellular receptors were sophisticated enough to both inhibit and activate signal transduction.
Periodical:
Journal of Biological Chemistry
Publisher:
American Society for Biochemistry and Molecular Biology
Location:
Box: 19. Folder: 9
Rights:
Reproduced with permission of the American Society for Biochemistry and Molecular Biology.
Genre:
Articles
Subject:
Adenylyl Cyclases, Cell Membrane, and Guanosine Triphosphate
Format:
Text
Extent:
5 pages
Relation:
Letter from Joshua Lederberg to Michael Doudoroff, 1949
Language:
English
Legacy Source Citation:
Periodical. Cooper, Dermot M. F., Werner Schlegel, Michael C. Lin, and Martin Rodbell. "The Fat Cell Adenylate Cyclase System: Characterization and Manipulation of Its Biomodal Regulation by GTP." Journal of Biological Chemistry 254, 18 (25 September 1979): 8927-8931. Article. 5 Images.. Journal of Biological Chemistry
Legacy ID:
GGAABC
NLM ID:
101584917X29
Profiles Collection:
The Martin Rodbell Papers
Story Section:
Signal Transduction and the Discovery of G-Proteins, 1969-1980