Signal Transduction: A Twenty Year History of G-Proteins


Title:
Signal Transduction: A Twenty Year History of G-Proteins
Creator:
Rodbell, Martin, 1925-1998
Date:
[ca. 1990]
Description:
In this portion of an unpublished manuscript, Rodbell briefly detailed how scientific knowledge evolved from studies on the regulation of adenylyl cyclase by hormones into recognition that sets of membrane receptors are linked to proteins that bind and degrade GTP (guanosine triphosphate).
Location:
Box: 20. Folder: 5
Rights:
Reproduced with permission of Martin Rodbell.
Genre:
Essays
Subject:
Adenylyl Cyclases, GTP-Binding Proteins, History of Medicine, History, 20th Century, and Hormones
Format:
Text
Extent:
5 pages
Relation:
Fig[ure]. 1: 1967 Conceptualization of an Hormone-Sensitive Adenylyl Cyclase, 1990
Fig[ure]. 2: 1969 Conceptualization of Adenylyl Cyclase System Stimulated by Multiple Hormones, 1990
Fig[ure]. 3: Early 1970 Representation of the Hormone Sensitive Adenylyl Cyclase As a System Formed of Three Functional Elements: Discriminator, Transducer, and Amplifier, 1990
Figure 4: Late 1970 Model of the Glucagon-Sensitive Liver Membrane Adenylyl Cyclase As an Information Transfer System, 1990
Fig[ure]. 5: 1977 Model of Hormonal Stimulation of an Adenylyl Cyclase System, 1990
Fig[ure]. 6: 1984 Model of Adenylyl Cyclase System Susceptible to Both Stimulatory and Inhibitory Regulation, 1990
Language:
English
Legacy ID:
GGAABN
NLM ID:
101584917X40
Profiles Collection:
The Martin Rodbell Papers
Story Section:
Cells as "Programmable Messengers," 1981-1994