Possible Mechanism of Tolerance to Narcotic Drugs


Title:
Possible Mechanism of Tolerance to Narcotic Drugs
Description:
While working on the metabolism of narcotic drugs, Axelrod observed that repeated administration of drugs produced tolerance to the drugs, but also reduced the body's ability to demethylate them enzymatically. In this article, he proposed a mechanism for tolerance to narcotic drugs. According to Axelrod, his hypothesis--that the continuous interaction of narcotic drugs with the demethylating enzymes deactivated the enzymes and possibly even the receptors of narcotic drugs, thus decreasing the subject's response to narcotic drugs--stimulated considerable criticism from some of his colleagues.
Extent:
2 pages
Date Issued:
10 August 1956
Creator:
Axelrod, Julius, 1912-2004
Source:
Periodical. Axelrod, Julius. "Possible Mechanism of Tolerance to Narcotic Drugs." Science 124, (10 August 1956): 263-264. Article. 2 Images.. Science
Periodical:
Science
Publisher:
American Association for the Advancement of Science
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission from the American Association for the Advancement of Science. Readers may view, browse, and/or download this material for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published, or sold in whole or in part, without prior written permission from AAAS. and http://www.sciencemag.org/
Subject:
Drug Tolerance and Narcotics
Profiles in Science ID:
HHAAAJ
NLM ID:
101584577X10
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 22. Folder: 9