Possible Mechanism of Tolerance to Narcotic Drugs
- Title:
- Possible Mechanism of Tolerance to Narcotic Drugs
- Creator:
- Axelrod, Julius, 1912-2004
- Date:
- 10 August 1956
- Description:
- While working on the metabolism of narcotic drugs, Axelrod observed that repeated administration of drugs produced tolerance to the drugs, but also reduced the body's ability to demethylate them enzymatically. In this article, he proposed a mechanism for tolerance to narcotic drugs. According to Axelrod, his hypothesis--that the continuous interaction of narcotic drugs with the demethylating enzymes deactivated the enzymes and possibly even the receptors of narcotic drugs, thus decreasing the subject's response to narcotic drugs--stimulated considerable criticism from some of his colleagues.
- Periodical:
- Science
- Publisher:
- American Association for the Advancement of Science
- Location:
- Box: 22. Folder: 9
- Rights:
- Reproduced with permission from the American Association for the Advancement of Science. Readers may view, browse, and/or download this material for temporary copying purposes only, provided these uses are for noncommercial personal purposes. Except as provided by law, this material may not be further reproduced, distributed, transmitted, modified, adapted, performed, displayed, published, or sold in whole or in part, without prior written permission from AAAS. and http://www.sciencemag.org/
- Genre:
- Articles
- Subject:
- Drug Tolerance and Narcotics
- Format:
- Text
- Extent:
- 2 pages
- Language:
- English
- Legacy Source Citation:
- Periodical. Axelrod, Julius. "Possible Mechanism of Tolerance to Narcotic Drugs." Science 124, (10 August 1956): 263-264. Article. 2 Images.. Science
- Legacy ID:
- HHAAAJ
- NLM ID:
- 101584577X10
- Profiles Collection:
- The Julius Axelrod Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584577X10
- Story Section:
- Work on the Sympathomimetic Amines, 1946-1958