Title:

The Distribution and Metabolism of Lysergic Acid Diethylamide

Creator:

Axelrod, Julius, 1912-2004
Brady, Roscoe O.
Evarts, Edward V.
Witkop, Bernhard, 1917-

Date:

14 March 1957

Description:

Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it was almost completely metabolized by the body, and found that their were considerable differences between various animal species in the rate of biotransformation of LSD.

Periodical:

Annals of the New York Academy of Sciences

Publisher:

New York Academy of Sciences

Location:

Box: 22. Folder: 9

Rights:

Reproduced with permission of the New York Academy of Sciences. Copies of Volume 66 are available through on-demand printing, and may be ordered directly from the Academy. Copies of individual articles may be ordered directly from the Academy or through Copyright Clearance Center. and http://www.nyas.org/

Genre:

Articles

Subject:

Microsomes, Lysergic Acid Diethylamide, and Metabolism

Format:

Text

Extent:

10 pages

Relation:

Blood Levels of LSD 25 in Cat, 1955

Language:

English

Legacy Source Citation:

Periodical. Axelrod, Julius, Roscoe O. Brady, Bernhard Witkop, and Edward V. Evarts. "The Distribution and Metabolism of Lysergic Acid Diethylamide." Annals of the New York Academy of Sciences 66, (14 March 1957): 435-444. Article. 10 Images.. Annals of the New York Academy of Sciences

Legacy ID:

HHAAAK

NLM ID:

101584577X11

Profiles Collection:

The Julius Axelrod Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584577X11

Story Section:

Work on the Sympathomimetic Amines, 1946-1958