Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine

Title:
Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine
Description:
This article was the first in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure. Through a variety of tests on several animals, Axelrod found two primary processes, demethylation and hydroxylation, that metabolically transformed ephedrine. He also noted that various animal species showed considerable differences in the relative importance of the two metabolic routes.
Extent:
12 pages
Date Issued:
September 1953
Creator:
Axelrod, Julius, 1912-2004
Source:
Periodical. Axelrod, Julius. "Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine." Journal of Pharmacology and Experimental Therapeutics 109, 1 (September 1953): 62-73. Article. 12 Images.. Journal of Pharmacology and Experimental Therapeutics
Periodical:
Journal of Pharmacology and Experimental Therapeutics
Publisher:
American Society for Pharmacology and Experimental Therapeutics
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the American Society for Pharmacology and Experimental Therapeutics. and http://www.aspet.org/
Subject:
Biotransformation and Sympathomimetics
Profiles in Science ID:
HHAAAG
NLM ID:
101584577X7
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 22. Folder: 4