Title:

Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine

Creator:

Axelrod, Julius, 1912-2004

Date:

September 1953

Description:

This article was the first in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure. Through a variety of tests on several animals, Axelrod found two primary processes, demethylation and hydroxylation, that metabolically transformed ephedrine. He also noted that various animal species showed considerable differences in the relative importance of the two metabolic routes.

Periodical:

Journal of Pharmacology and Experimental Therapeutics

Publisher:

American Society for Pharmacology and Experimental Therapeutics

Location:

Box: 22. Folder: 4

Rights:

Reproduced with permission of the American Society for Pharmacology and Experimental Therapeutics. and http://www.aspet.org/

Genre:

Articles

Subject:

Biotransformation and Sympathomimetics

Format:

Text

Extent:

12 pages

Relation:

Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine, 1954
The Enzymatic Deamination of Amphetamine (Benzedrine), 1955

Language:

English

Legacy Source Citation:

Periodical. Axelrod, Julius. "Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine." Journal of Pharmacology and Experimental Therapeutics 109, 1 (September 1953): 62-73. Article. 12 Images.. Journal of Pharmacology and Experimental Therapeutics

Legacy ID:

HHAAAG

NLM ID:

101584577X7

Profiles Collection:

The Julius Axelrod Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584577X7

Story Section:

Work on the Sympathomimetic Amines, 1946-1958