Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine


Title:
Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine
Description:
In this second in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure, Axelrod found that the fate and physiological disposition of compounds of amphetamine in several species of animals was metabolized by a number of biochemical processes, including hydroxylation, demethylation, deamination, and conjugation. Axelrod again determined that various species showed considerable variations in the ways in which their bodies transformed these drugs.
Extent:
13 pages
Date Issued:
March 1954
Creator:
Axelrod, Julius, 1912-2004
Source:
Periodical. Axelrod, Julius. "Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine." Journal of Pharmacology and Experimental Therapeutics 110, 3 (March 1954): 315-326. Article. 13 Images.. Journal of Pharmacology and Experimental Therapeutics
Periodical:
Journal of Pharmacology and Experimental Therapeutics
Publisher:
American Society for Pharmacology and Experimental Therapeutics
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the American Society for Pharmacology and Experimental Therapeutics. and http://www.aspet.org/
Subject:
Biotransformation, Sympathomimetics, and Metabolism
Profiles in Science ID:
HHAAAH
NLM ID:
101584577X8
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 22. Folder: 5