Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine

Title:
Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine
Creator:
Axelrod, Julius, 1912-2004
Date:
March 1954
Description:
In this second in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure, Axelrod found that the fate and physiological disposition of compounds of amphetamine in several species of animals was metabolized by a number of biochemical processes, including hydroxylation, demethylation, deamination, and conjugation. Axelrod again determined that various species showed considerable variations in the ways in which their bodies transformed these drugs.
Periodical:
Journal of Pharmacology and Experimental Therapeutics
Publisher:
American Society for Pharmacology and Experimental Therapeutics
Location:
Box: 22. Folder: 5
Rights:
Reproduced with permission of the American Society for Pharmacology and Experimental Therapeutics. and http://www.aspet.org/
Genre:
Articles
Subject:
Biotransformation, Sympathomimetics, and Metabolism
Format:
Text
Extent:
13 pages
Relation:
Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine, 1953
The Enzymatic Deamination of Amphetamine (Benzedrine), 1955
Language:
English
Legacy Source Citation:
Periodical. Axelrod, Julius. "Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine." Journal of Pharmacology and Experimental Therapeutics 110, 3 (March 1954): 315-326. Article. 13 Images.. Journal of Pharmacology and Experimental Therapeutics
Legacy ID:
HHAAAH
NLM ID:
101584577X8
Profiles Collection:
The Julius Axelrod Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584577X8
Story Section:
Work on the Sympathomimetic Amines, 1946-1958