Title:

The Enzymatic Deamination of Amphetamine (Benzedrine)

Creator:

Axelrod, Julius, 1912-2004

Date:

June 1955

Description:

Part of long series of research articles on the role played in the body by sympathetic amines, in this paper, Axelrod compared the transformation of amphetamine in rabbits to rats, dogs, and guinea pigs. The subject of the article originated in Axelrod's curiosity as to why when amphetamine was administered to rabbits it disappeared entirely. Axelrod found in this article that one or several enzymes in a rabbit's liver deaminated amphetamine, leading to the formation of phenylacetone and ammonia. He also determined that ephedrine was similarly demethylated to norephedrine and formaldehyde by the microsomal drug metabolizing enzymes.

Periodical:

Journal of Biological Chemistry

Publisher:

American Society for Biochemistry and Molecular Biology

Location:

Box: 22. Folder: 7

Rights:

Reproduced with permission of the American Society for Biochemistry and Molecular Biology.

Genre:

Articles

Subject:

Microsomes, Amphetamine, and Deamination

Format:

Text

Extent:

12 pages

Relation:

Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine, 1953
Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine, 1954

Language:

English

Legacy Source Citation:

Periodical. Axelrod, Julius. "The Enzymatic Deamination of Amphetamine (Benzedrine)." Journal of Biological Chemistry 214, 2 (June 1955): 753-763. Article. 12 Images.. Journal of Biological Chemistry

Legacy ID:

HHAAAI

NLM ID:

101584577X9

Profiles Collection:

The Julius Axelrod Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584577X9

Story Section:

Work on the Sympathomimetic Amines, 1946-1958