Title:

Approximation of Genetic Code Via Cell-Free Protein Synthesis Directed by Template RNA

Creator:

Nirenberg, Marshall W.
Barondes, Samuel H., 1933-
Martin, Robert G.
Jones, Oliver W., Jr
Matthaei, Heinrich

Date:

[January-February 1963]

Description:

This article offers a solution to the technical problems of a direct biochemical approach to deciphering the genetic code. Comparison of the nucleotide sequence of a gene with the amino acid sequence of its corresponding protein remained problematic as the sequence of nucleotides in each coding was initially unknown. The authors demonstrate with experimental evidence that there are only a certain number of possible nucleotides per code word. Additionally, by using tobacco mosaic virus RNA to direct the cell-free synthesis of a protein resembling TMV, the experiment suggests at least part of the genetic code appears to be universal.

Periodical:

Federation Proceedings

Publisher:

Federation of American Societies for Experimental Biology

Rights:

Reproduced with permission of the Federation of American Societies for Experimental Biology.

Genre:

Articles

Subject:

DNA, RNA, and RNA, Messenger

Format:

Text

Extent:

7 pages

Language:

English

Legacy Source Citation:

Periodical. Nirenberg, Marshall W., J. Heinrich Matthaei, Oliver W. Jones Jr, Robert G. Martin, and Samuel H. Barondes. "Approximation of Genetic Code Via Cell-Free Protein Synthesis Directed by Template RNA." Federation Proceedings 22, ([January-February 1963]): 55-61. Article. 7 Images.. Federation Proceedings

Legacy ID:

JJBBJJ

NLM ID:

101584910X133

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X133

Story Section:

Translating the Code of Life and the Nobel Prize, 1962-1968