Title:

Regulation of Acetylcholinesterase in Neuroblastoma Cells

Creator:

Blume, Arthur J.
Gilbert, F.
Nirenberg, Marshall W.
Wilson, S.
Farber, John L.
Rosenberg, Roger N.

Date:

October 1970

Description:

This article is one of the first published reports of Marshall Nirenberg's work during his transitional move toward neurobiological investigation. Experimental findings in the article show that when tumor cells shift from the dividing to the non-dividing state, they are influenced by the expression of a set of genetic characteristics required for neuron differentiation. As progeny cells remained committed to a program of neuron differentiation, the authors anticipated implications for the study of healthy neurons--the "possibility" that "normal sympathetic neuroblasts are also inversely committed to a pattern of neuronal differentiation."

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy Press (U.S.)

Rights:

Reproduced with permission of Marshall W. Nirenberg.

Genre:

Articles

Subject:

Neuroblastoma, Cell Transformation, Neoplastic, Enzyme Activation, and Acetylcholinesterase

Format:

Text

Extent:

7 pages

Language:

English

Legacy Source Citation:

Periodical. Blume, Arthur J., F. Gilbert, S. Wilson, John L. Farber, Roger N. Rosenberg, and Marshall W. Nirenberg. "Regulation of Acetylcholinesterase in Neuroblastoma Cells." Proceedings of the National Academy of Sciences of the United States of America 67, 2 (October 1970): 786-792. Article. 7 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

JJBBMY

NLM ID:

101584910X208

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X208

Story Section:

Neuroblastoma Research, 1967-1976