Title:

Genes for Neuronal Properties Expressed in Neuroblastoma x L Cell Hybrids

Creator:

Peacock, John
Nirenberg, Marshall W.
Minna, John, 1941-
Nelson, Phillip G.
Glazer, Devera

Date:

January 1971

Description:

As part of Marshall Nirenberg's early work in neurobiology, this early article uses neuroblastoma systems to explore steps in the maturation process as well as aspects of neural function. Somatic cell hybrids are shown to possess the "neuronal property of electrically excitable membranes." The authors hope to apply these findings to promote neuronal differentiation in normal neuroblasts. The article provides evidence that "at least part of the genetic information for neuron differentiation can be functionally expressed in" hybrid cells.

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy Press (U.S.)

Rights:

Reproduced with permission of Marshall W. Nirenberg.

Genre:

Articles

Subject:

Neuroblastoma, Hybridization, Genetic, Cell Differentiation, Membrane Potentials, Genes, and L Cells (Cell Line)

Format:

Text

Extent:

6 pages

Language:

English

Legacy Source Citation:

Periodical. Minna, John, Phillip Nelson, John Peacock, Devera Glazer, and Marshall W. Nirenberg. "Genes for Neuronal Properties Expressed in Neuroblastoma x L Cell Hybrids." Proceedings of the National Academy of Sciences of the United States of America 68, 1 (January 1971): 234-239. Article. 6 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

JJBBMZ

NLM ID:

101584910X209

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X209

Story Section:

Neuroblastoma Research, 1967-1976