Title:

Morphine Receptors as Regulators of Adenylate Cyclase Activity

Creator:

Nirenberg, Marshall W.
Sharma, S. K. (Shail K.)
Klee, Werner A.

Date:

February 1975

Description:

This article is an extension of earlier published work describing the neuroblastoma hybrid cell line and examining the effects of morphine and other narcotics upon enzyme activity. The authors find that morphine and other narcotics inhibit enzyme activity and that the inhibition is dependent upon morphine receptors. This leads to a hypothesis concerning the molecular basis for narcotic addiction and tolerance at the end of the article.

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy Press (U.S.)

Rights:

Reproduced with permission of Marshall W. Nirenberg.

Genre:

Articles

Subject:

Adenylyl Cyclases, Tumor Cells, Cultured, and Receptors, Opioid, mu

Format:

Text

Extent:

5 pages

Relation:

Dual Regulation of Adenylate Cyclase Accounts for Narcotic Dependence and Tolerance, 1975

Language:

English

Legacy Source Citation:

Periodical. Sharma, Shail K., Marshall W. Nirenberg, and Werner A. Klee. "Morphine Receptors as Regulators of Adenylate Cyclase Activity." Proceedings of the National Academy of Sciences of the United States of America 72, 2 (February 1975): 590-594. Article. 5 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

JJBBNH

NLM ID:

101584910X215

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X215

Story Section:

Neuroblastoma Research, 1967-1976