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Dual Regulation of Adenylate Cyclase Accounts for Narcotic Dependence and Tolerance
- Title:
- Dual Regulation of Adenylate Cyclase Accounts for Narcotic Dependence and Tolerance
- Creator:
- Nirenberg, Marshall W.
Sharma, S. K. (Shail K.)
Klee, Werner A. - Date:
- August 1975
- Description:
- This article is an extension of the article titled, "Morphine Receptors as Regulators of Adenylate Cyclase Activity." The dependence and tolerance phenomenon involving enzymes and morphine receptors is explained as follows: narcotics affect enzymes in two opposing ways, each mediated by the opiate receptor. One process is responsible for the inhibition of the enzyme by narcotics, the other is a compensatory increase in enzyme activity, which is delayed in onset and relatively stable. Narcotics dependence and tolerance is the result of the positive regulation of the enzyme counteracting the inhibitory influence of the morphine. Furthermore, the inhibitory and positive regulatory mechanisms provide a means for "activating and deactivating neural circuits hours after the initial event and thus may play a role in memory process."
- Periodical:
- Proceedings of the National Academy of Sciences of the United States of America
- Publisher:
- National Academy Press (U.S.)
- Rights:
- Reproduced with permission of Marshall W. Nirenberg.
- Genre:
- Articles
- Subject:
- Adenylyl Cyclases, Narcotics, and Receptors, Cell Surface
- Format:
- Text
- Extent:
- 5 pages
- Relation:
- Morphine Receptors as Regulators of Adenylate Cyclase Activity, 1975
- Language:
- English
- Legacy Source Citation:
- Periodical. Sharma, Shail K., Werner A. Klee, and Marshall W. Nirenberg. "Dual Regulation of Adenylate Cyclase Accounts for Narcotic Dependence and Tolerance." Proceedings of the National Academy of Sciences of the United States of America 72, 8 (August 1975): 3092-3096. Article. 5 Images.. Proceedings of the National Academy of Sciences of the United States of America
- Legacy ID:
- JJBBNJ
- NLM ID:
- 101584910X216
- Profiles Collection:
- The Marshall W. Nirenberg Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584910X216
- Story Section:
- Neuroblastoma Research, 1967-1976