Title:

Tolerance and Dependence Evoked by an Endogenous Opiate Peptide

Creator:

Nirenberg, Marshall W.
Lampert, Arthur
Klee, Werner A.

Date:

September 1976

Description:

As part of an ongoing series of articles devoted to the topic, this article provides experimental evidence that the dual regulation of enzyme production by narcotics accounts for the phenomenon of narcotic dependence and tolerance. Additionally, results show that cells become tolerant and dependent on certain peptides, suggesting that "tolerance and dependence are normal responses which regulate transynoptic communication" coupled to enzyme activity.

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy Press (U.S.)

Rights:

Reproduced with permission of Marshall W. Nirenberg.

Genre:

Articles

Subject:

Adenylyl Cyclases, Receptors, Opioid, and Opioid Peptides

Format:

Text

Extent:

3 pages

Language:

English

Legacy Source Citation:

Periodical. Lampert, Arthur, Marshall W. Nirenberg, and Werner A. Klee. "Tolerance and Dependence Evoked by an Endogenous Opiate Peptide." Proceedings of the National Academy of Sciences of the United States of America 73, 9 (September 1976): 3165-3167. Article. 3 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

JJBBNK

NLM ID:

101584910X217

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X217

Story Section:

Neuroblastoma Research, 1967-1976