Title:

Laboratory project: "Acetylcholine Receptor-Mediated Regulation of Adenylate Cyclase in Hybrid Cells"

Creator:

Nirenberg, Marshall W.
National Heart and Lung Institute. Laboratory of Biochemical Genetics
Nathanson, Neil M.

Date:

September 1976

Description:

Summary of work on this project as indicated on the report: "The activity of adenylate cyclase in neuroblastoma x glioma hybrid NG108-15 cells is regulated by the interaction of acetylcholine and its analogues with the muscarinic acetylcholine receptors of the cells. Addition of the acetylcholine analogue carbamylcholine inhibits adenylate cyclase activity. However, growth of cells with carbachol results in a prolonged increase in adenylate cyclase activity. Adenylate cyclase activity increases slowly and after 18-24 hours is 1.5-3 times higher than control values. Intracellular cAMP is also 1.5-3 -fold times higher in carbachol-grown cells than in controls. These changes are maintained for at least three days in the presence of carbachol, but the activity returns to control values if carbachol is removed."

Location:

Box: 31 of 31

Rights:

Public Domain

Genre:

Reports
Excerpts

Format:

Text

Extent:

2 pages

Relation:

Annual Report of the Laboratory of Biochemical Genetics, October 1, 1975 - September 30, 1976, 1976

Language:

English

Legacy ID:

JJBBNX

NLM ID:

101584910X226

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X226

Story Section:

Neuroblastoma Research, 1967-1976