Title:

Laboratory project: "Regulation of Cyclic Nucleotide Biosynthesis by Neurotransmitters and Opiates"

Creator:

Sabol, Steven L.
Nirenberg, Marshall W.
National Heart and Lung Institute. Laboratory of Biochemical Genetics

Date:

September 1976

Description:

Summary of work on this project as indicated on the report: "The role of the cyclic nucleotides adenosine 3'5' monophosphate and guanosine 3'5' monophosphate in synaptic transmission is under study using cultured cells of neutral origin. The topics of interest during the current year have been the following: 1) The receptor-mediated inhibition of adenylate cyclase activity by alpha-adrenergic agents in neuroblastoma x glioma hybrid cells; 2) Demonstration of a compensatory induction of adenylate cyclase activity in cells treated for one or more days with alpha-adrenergic agents, as had been previously demonstrated by others for opiates, and study of the mechanism of this compensatory induction; 3) The effect of opiates and alpha-adrenergic agents on guanosine 3'5' monophosphate levels in the hybrid cells; 4) Search for a cultured-cell system which synthesizes a peptide with opiate-like properties."

Location:

Box: 31 of 31

Rights:

Public Domain

Genre:

Reports
Excerpts

Format:

Text

Extent:

2 pages

Relation:

Annual Report of the Laboratory of Biochemical Genetics, October 1, 1975 - September 30, 1976, 1976

Language:

English

Legacy ID:

JJBBPD

NLM ID:

101584910X231

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X231

Story Section:

Neuroblastoma Research, 1967-1976