Title:

Laboratory project: "Acetylcholine Receptors"

Creator:

Daniels, Mathew P.
Vogel, Zvi
Nirenberg, Marshall W.
National Heart, Lung, and Blood Institute. Laboratory of Biochemical Genetics
Nelson, Phillip G.
Bauer, Hans
Prives, Joav
Schaffner, Anne
Christian, Clifford

Date:

September 1979

Description:

Summary of work on this project as indicated on the report: "Our aim is to study the distribution of nicotinic acetylcholine receptors in intact and cultured tissues of the peripheral and central nervous system in relationship to the development and function of synapses. To this purpose histochemical localization of alpha-bungarotoxin bound to the receptors is used in conjunction with light and electron microscopy. In the past year we have continued our study of the formation of cholinergic synapses in developing chick embryos, using an alpha-bugartoxin(sic)-horseradish peroxidase conjugate; we have extended our studies on the control of nicotinic acetylcholine receptor aggregation on cultured skeletal muscle cells by macromolecular factors secreted by the neuroblastoma-glioma hybrid cells and embryonic neurons; and we have initiated work on the structural interaction between the cytoskeleton and nicotinic acetylcholine receptors in cultured skeletal muscle cells.

Location:

Box: 6. Folder: 22

Rights:

Public Domain

Genre:

Reports
Excerpts

Format:

Text

Extent:

3 pages

Relation:

Annual Report of the Laboratory of Biochemical Genetics, October 1, 1978 - September 30, 1979, 1979

Language:

English

Legacy ID:

JJBBQH

NLM ID:

101584910X255

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X255

Story Section:

From Neuroblastoma to Homeobox Genes, 1976-1992