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This article describes experiments in which RNA is synthesized in an in vitro system derived from E. coli. The synthesized RNA is found to behave essentially like the "undegraded" messenger-RNA detectable in growing E. coli cells. The ability to synthesize this process was crucial in deciphering the genetic code.
Periodical:
Proceedings of the National Academy of Sciences of the United States of America
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Periodical. Otaka, E., H. Mitsui, and S. Osawa. "On the Ribonucleic Acid Synthesized in a Cell-Free System of Escherichia Coli." Proceedings of the National Academy of Sciences of the United States of America 48, (15 March 1962): 425-430. Article. 6 Images.. Proceedings of the National Academy of Sciences of the United States of America