Title:

Characteristics and Stabilization of DNAase-Sensitive Protein Synthesis in E. Coli Extracts

Creator:

Nirenberg, Marshall W.
Matthaei, Heinrich

Date:

October 1961

Description:

This innovative article is one of Nirenberg's most important early contributions to the coding problem. Published along with "The Dependence of Cell-Free Protein Synthesis in E. coli Upon Naturally Occurring or Synthetic Polyribonucleotides," this article provides experimental evidence that an extract prepared from bacterial cells can make protein even when intact living cells are not present. This revelation is a crucial step in the history of breaking the genetic code.

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy of Sciences (U.S.)

Rights:

Reproduced with permission of Marshall W. Nirenberg.

Genre:

Articles

Subject:

Escherichia coli and Deoxyribonucleases

Format:

Text

Extent:

9 pages

Relation:

The Dependence of Cell-Free Protein Synthesis in E. Coli Upon Naturally Occuring or Synthetic Polyribonucleotides, 1961

Language:

English

Legacy Source Citation:

Periodical. Matthaei, J. Heinrich, and Marshall W. Nirenberg. "Characteristics and Stabilization of DNAase-Sensitive Protein Synthesis in E. Coli Extracts." Proceedings of the National Academy of Sciences of the United States of America 47, 10 (October 1961): 1580-1588. Article. 9 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

JJBBDJ

NLM ID:

101584910X49

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X49

Story Section:

Synthetic RNA and the Poly-U Experiments, 1959-1962