Title:

Synapse Turnover: A Mechanism for Acquiring Synaptic Specificity

Creator:

Thompson, Jeffrey M.
Eisenbarth, George S.
Ruffolo, Robert R.
Nirenberg, Marshall W.

Date:

May 1978

Description:

In previous studies on synapse formation, "chick embryo retina neurons were shown to form synapses rapidly with striated muscle cells" but were transient and eventually disappeared. This report uses striated muscle cells to define the number of neurons that are able to form synapses at different stages of development and suggests that both correct and incorrect synapses are formed during normal embryonic development, with correctly matched synapses being retained.

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy of Sciences (U.S.)

Rights:

Reproduced with permission of Marshall W. Nirenberg.

Genre:

Articles

Subject:

Neuromuscular Junction and Synapses

Format:

Text

Extent:

5 pages

Language:

English

Legacy Source Citation:

Periodical. Ruffolo, Robert R. Jr, George S. Eisenbarth, Jeffrey M. Thompson, and Marshall W. Nirenberg. "Synapse Turnover: A Mechanism for Acquiring Synaptic Specificity." Proceedings of the National Academy of Sciences of the United States of America 75, 5 (May 1978): 2281-2285. Article. 5 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

JJBBFC

NLM ID:

101584910X65

Profiles Collection:

The Marshall W. Nirenberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584910X65

Story Section:

From Neuroblastoma to Homeobox Genes, 1976-1992