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One of the key discoveries in early code translation efforts is discussed in this article--that single-stranded RNA, but not double or triple stranded RNA, serves as a template for protein synthesis. This article discusses the possible functional significance of RNA's secondary structure in the coding mechanism.
Periodical:
Proceedings of the National Academy of Sciences of the United States of America
Periodical. Singer, Maxine, Oliver W. Jones Jr, and Marshall W. Nirenberg. "The Effect of Secondary Structure on the Template Activity of Polyribonucleotides." Proceedings of the National Academy of Sciences of the United States of America 49, 3 (March 1963): 392-399. Article. 8 Images.. Proceedings of the National Academy of Sciences of the United States of America