A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase


Title:
A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase
Description:
In this article, Anfinsen, Epstein, Goldberger, and Young reported their findings of the rate and extent of return of enzymatic activity during oxidation of the sulfhydryl groups of reduced ribonuclease that they studied under a variety of conditions. They found that the rate of reactivation was inversely proportional to the concentration of the reduced portion of ribonuclease. Because of this, these results were inconsistent with the then-prevailing hypothesis that information necessary for the conversion of a newly synthesized polypeptide chain to the native form of the protein resided in the amino acid sequence and did not involve a genetically determined template.
Extent:
9 pages
Date Issued:
1962
Creator:
Epstein, Charles (Charles Epstein), Goldberger, Robert E., 1937-, Young, D. Michael, 1944-, and Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Source:
Periodical. Epstein, Charles, Robert Goldberger, D. Michael Young, and Christian B. Anfinsen. "A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase." Archives of Biochemistry and Biophysics Supplement, (1962): 223-231. Article. 9 Images.. Archives of Biochemistry and Biophysics
Periodical:
Archives of Biochemistry and Biophysics
Publisher:
The Academic Press
Right Type:
Public Domain
Subject:
Ribonucleases, Disulfides, Enzymes, and Peptides
Profiles in Science ID:
KKBBJW
NLM ID:
101584571X143
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 27. Folder: 5