Title:

Purification and Properties of a Microsomal Enzyme System Catalyzing the Reactivation of Reduced Ribonuclease and Lysozyme

Creator:

Goldberger, Robert E., 1937-
Epstein, Charles
Anfinsen, Christian B. (Christian Boehmer), 1916-1995

Date:

1964

Description:

In this follow-up to an earlier article, Anfinsen, Goldberger, and Epstein reported "the solubilization and partial purification of the active microsomal protein," and described some of the properties of the soluble system. This and other studies seemed to make clear that the integrity of microsomes as organized particles was not required for catalyzing the reactivation of the reduced forms of ribonuclease and lysozyme. Their findings suggested that the microsomal system might function to facilitate the conversion of at least two different polypeptide chains to the corresponding native proteins during the synthesis of most proteins containing disulfide bonds.

Periodical:

Journal of Biological Chemistry

Publisher:

American Society for Biochemistry and Molecular Biology

Location:

Box: 27. Folder: 8

Rights:

Reproduced with permission of the American Society for Biochemistry and Molecular Biology. and http://www.jbc.org/

Genre:

Articles

Subject:

Microsomes, Ribonucleases, Enzymes, Oxidation-Reduction, and Research Design

Format:

Text

Extent:

5 pages

Relation:

Acceleration of Reactivation of Reduced Bovine Pancreatic Ribonuclease by a Microsomal System from Rat Liver, 1963

Language:

English

Legacy Source Citation:

Periodical. Goldberger, Robert, Charles Epstein, and Christian B. Anfinsen. "Purification and Properties of a Microsomal Enzyme System Catalyzing the Reactivation of Reduced Ribonuclease and Lysozyme." Journal of Biological Chemistry 239, 5 (1964): 1406-1410. Article. 5 Images.. Journal of Biological Chemistry

Legacy ID:

KKBBJY

NLM ID:

101584571X145

Profiles Collection:

The Christian B. Anfinsen Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584571X145