Title:

Kinetics of Folding of Staphylococcal Nuclease

Creator:

Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Schechter, Alan N.
Chen, Raymond F.

Date:

6 February 1970

Description:

In this article, Anfinsen, Schecter, and Chen reported one of the first direct measurements of the folding of proteins to their native conformation from a disordered state by use of a stopped-flow spectrofluorometer. Understanding protein folding was seen as an essential intermediate step to obtaining the information of the genetic code for the biological function of the corresponding protein or polypeptide chain.

Periodical:

Science

Publisher:

American Association for the Advancement of Science

Location:

Box: 27. Folder: 14

Rights:

http://www.sciencemag.org/

Genre:

Articles

Subject:

Protein Conformation, Protein Denaturation, and Enzymes

Format:

Text

Extent:

2 pages

Language:

English

Legacy Source Citation:

Periodical. Schechter, Alan N., Raymond F. Chen, and Christian B. Anfinsen. "Kinetics of Folding of Staphylococcal Nuclease." Science 167, (6 February 1970): 886-887. Article. 2 Images.. Science

Legacy ID:

KKBBKH

NLM ID:

101584571X152

Profiles Collection:

The Christian B. Anfinsen Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584571X152

Story Section:

Molecular Engineering and Affinity Chromatography, 1959-1972