Amino Acid Residues Essential for Biological Activity of a Peptide Derived From a Major Histocompatibility Complex Class I Antigen


Title:
Amino Acid Residues Essential for Biological Activity of a Peptide Derived From a Major Histocompatibility Complex Class I Antigen
Description:
In this article, Anfinsen, in collaboration with a number of scientists at laboratories across the United States, reported his observations on the self interaction of peptides from the alpha-1 domain of the major histocampatibility complex (MHC) class I antigen. The authors noted that this self interaction, in the absence of cells and form aggregates that precipitate upon centrifugation, suggested that the biological effects in cells, which result from inhibition of receptor and transporter internalization, may be due to the binding of the peptide to the homologous sequences in the alpha-1 domain of the MHC class I molecule. The researchers suggested that MHC class I molecules, which function in the immune system to transport antigenic peptides to the cell surface, might also play a role in receptor recycling.
Extent:
5 pages
Date Issued:
1993
Creator:
Stagsted, Jan (Jan Stagsted), Mapelli, Claudio (Claudio Mapelli), Meyers, Chester (Chester Meyers), Matthews, Brian W. (Brian W. Matthews), Anfinsen, Christian B. (Christian Boehmer), 1916-1995, Goldstein, Avram, and Olsson, Lennart (Lennart Olsson)
Source:
Periodical. Stagsted, Jan, Claudio Mapelli, Chester Meyers, Brian W. Matthews, Christian B. Anfinsen, Avram Goldstein, and Lennart Olsson. "Amino Acid Residues Essential for Biological Activity of a Peptide Derived From a Major Histocompatibility Complex Class I Antigen." Proceedings of the National Academy of Sciences of the United States of America 90, (1993): 7686-7690. Article. 5 Images.. Proceedings of the National Academy of Sciences of the United States of America
Periodical:
Proceedings of the National Academy of Sciences of the United States of America
Publisher:
National Academy Press (U.S.)
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of the National Academy of Sciences (U.S.). and http://www.pnas.org/
Subject:
Amino Acid Sequence, Protein Conformation, Histocompatibility, and Peptides
Profiles in Science ID:
KKBBKQ
NLM ID:
101584571X159
Genre:
Articles
Language:
English
Format:
Text
Location:
Box: 28. Folder: 7