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Studies on the Structural Basis of Ribonuclease Activity
- Title:
- Studies on the Structural Basis of Ribonuclease Activity
- Creator:
- Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Schellman, John
Hvidt, Aase
Linderstrøm-Lang, Kaj, 1896-
Harrington, William F.
Ottensen, Martin - Date:
- 1955
- Description:
- This brief note was the product of Anfinsen's one-year postdoctoral fellowship from the Rockefeller Foundation at the Carlsberg Laboratory in Copenhagen. It was Anfinsen's second tour at the laboratory; his first in 1939-1940 was cut short due the outbreak of World War II. Working with the Danish biochemist Kaj Linderstrom-Lang and others, Anfinsen conducted an in-depth physical analysis of the structure of ribonuclease, or Rnase. The group suggested that only a relatively small part of the Rnase molecule, the "active center," is directly involved in catalytic activity, and therefore an ordered secondary structure in a protein was unnecessary for its properties as a catalyst. This conclusion was largely disproven by Anfinsen's subsequent research into amino acid sequencing and protein folding in the 1960s.
- Periodical:
- Biochimica et Biophysica Acta
- Publisher:
- Amsterdam Elsevier
- Location:
- Box: 26. Folder: 15
- Rights:
- Reproduced with permission of Elsevier Science Publishers. and http://www.elsevier.com/
- Genre:
- Articles
- Format:
- Text
- Extent:
- 2 pages
- Relation:
- Commentary by Christian B. Anfinsen on 'Studies on the Structural Basis of Ribonuclease Activity', 1989 Letter from Christian B. Anfinsen to Bernard D. Davis, 1989
- Language:
- English
- Legacy Source Citation:
- Periodical. Anfinsen, Christian B., William F. Harrington, Aase Hvidt, Kaj Linderstrom-Lang, Martin Ottensen, and John Schellman. "Studies on the Structural Basis of Ribonuclease Activity." Biochimica et Biophysica Acta 17, (1955): 141-142. Article. 2 Images.. Biochimica et Biophysica Acta
- Legacy ID:
- KKBBKW
- NLM ID:
- 101584571X164
- Profiles Collection:
- The Christian B. Anfinsen Papers
- Shareable Link:
- https://profiles.nlm.nih.gov/101584571X164
- Story Section:
- Protein Folding and the Thermodynamic Hypothesis, 1950-1962