Title:

Some Relationships of Structure to Function in Ribonuclease

Creator:

Anfinsen, Christian B. (Christian Boehmer), 1916-1995
White, F. H., Jr

Date:

4 September 1959

Description:

This study by White and Anfinsen on the renaturation of fully denatured ribonuclease, or RNase, required subsequent supporting investigations to establish what came to be called the "thermodynamic hypothesis." Here they reported that RNase activity depended upon a variety of structural features, but noted that it could be inferred from the results of their experimentation that only a small part of the enzyme molecule, what they termed the "active center," was necessary for catalyst.

Periodical:

Annals of the New York Academy of Sciences

Publisher:

New York Academy of Sciences

Location:

Box: 27. Folder: 4

Rights:

Reproduced with permission of the New York Academy of Sciences. and http://www.nyas.org/

Genre:

Articles

Subject:

Ribonucleases, Oxidation-Reduction, Protein Conformation, and Disulfides

Format:

Text

Extent:

9 pages

Language:

English

Legacy Source Citation:

Periodical. White, F. H. Jr, and Christian B. Anfinsen. "Some Relationships of Structure to Function in Ribonuclease." Annals of the New York Academy of Sciences 81, 3 (4 September 1959): 515-523. Article. 9 Images.. Annals of the New York Academy of Sciences

Legacy ID:

KKBBKY

NLM ID:

101584571X166

Profiles Collection:

The Christian B. Anfinsen Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584571X166