Title:

Nuclease-T: An Active Derivative of Staphylococcal Nuclease Composed of Two Noncovalently Bonded Peptide Fragments

Creator:

Sodja, Ann
Taniuchi, Horoshi
Anfinsen, Christian B. (Christian Boehmer), 1916-1995

Date:

September 1967

Description:

This is one of many articles produced by Anfinsen's research team and others on the factors contributing to the translation of the genetic message for a particular protein backbone. Taniuchi, Sodja, and Anfinsen determined that such a translation was no longer possible if the linear information had been manipulated through the deletion of amino acid residues. However, they did find that some proteins that they termed "recombining systems" could be cleaved into two, or even three, fragments that recombined through non-covalent forces to yield biologically active structures with physical properties very similar to those of the parent protein molecules.

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy Press (U.S.)

Location:

Box: 27. Folder: 10

Rights:

Reproduced with permission of Libby Anfinsen.

Genre:

Articles

Subject:

Peptide Mapping, Enzymes, Research Design, and Staphylococcus aureus

Format:

Text

Extent:

8 pages

Language:

English

Legacy Source Citation:

Periodical. Taniuchi, Horoshi, Christian B. Anfinsen, and Ann Sodja. "Nuclease-T: An Active Derivative of Staphylococcal Nuclease Composed of Two Noncovalently Bonded Peptide Fragments." Proceedings of the National Academy of Sciences of the United States of America 58, 3 (September 1967): 1235-1242. Article. 8 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

KKBBLD

NLM ID:

101584571X170

Profiles Collection:

The Christian B. Anfinsen Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584571X170