Title:

An Immunologic Approach to the Conformational Equilibria of Polypeptides

Creator:

Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Sachs, David H. (David Howard), 1942-
Schechter, Alan N.
Eastlake, Ann

Date:

December 1972

Description:

Certain antibodies are particularly well-suited for the study of the conformational equilibria of polypeptide fragments of nuclease in solution. Here, Anfinsen, Schechter, Sachs, and Eastlake hypothesized that such fragments actually existed in solution in conformational equilibrium, components of which were sufficiently similar to the native conformation that antibodies directed to the native molecule could bind. They were able to validate this hypothesis by using synthetic polypeptide fragments, which were already known to induce folding of complimentary fragments.

Periodical:

Proceedings of the National Academy of Sciences of the United States of America

Publisher:

National Academy Press (U.S.)

Location:

Box: 28. Folder: 4

Rights:

Reproduced with permission of Libby Anfinsen.

Genre:

Articles

Subject:

Antigen-Antibody Reactions, Protein Conformation, Antibody Specificity, and Epitopes

Format:

Text

Extent:

5 pages

Language:

English

Legacy Source Citation:

Periodical. Sachs, David H., Alan N. Schechter, Ann Eastlake, and Christian B. Anfinsen. "An Immunologic Approach to the Conformational Equilibria of Polypeptides." Proceedings of the National Academy of Sciences of the United States of America 69, 12 (December 1972): 3790-3794. Article. 5 Images.. Proceedings of the National Academy of Sciences of the United States of America

Legacy ID:

KKBBLL

NLM ID:

101584571X176

Profiles Collection:

The Christian B. Anfinsen Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584571X176