Title:

Reductive Cleavage of Disulfide Bridges in Ribonuclease

Creator:

White, Frederick H.
Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Sela, Michael

Date:

12 April 1957

Description:

This article was the first of many studies that were generally concerned with the eventual total synthesis of the protein. It contained several original observations that would lead to the conclusion that the refolding of the ribonuclease molecule after full denaturation by reductive cleavage of its four disulfide bonds required that only one of the one hundred five possible pairings of eight sulfhydryl groups to form four disulfide linkages take place.

Periodical:

Science

Publisher:

American Association for the Advancement of Science

Rights:

Courtesy of Science Magazine.

Genre:

Articles

Format:

Text

Extent:

3 pages

Language:

English

Legacy Source Citation:

Periodical. Sela, Michael, Frederick H. White, and Christian B. Anfinsen. "Reductive Cleavage of Disulfide Bridges in Ribonuclease." Science 125, 3250 (12 April 1957): 691-692. Article. 3 Images.. Science

Legacy ID:

KKBBLT

NLM ID:

101584571X182

Profiles Collection:

The Christian B. Anfinsen Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584571X182