Reductive Cleavage of Disulfide Bridges in Ribonuclease


Title:
Reductive Cleavage of Disulfide Bridges in Ribonuclease
Description:
This article was the first of many studies that were generally concerned with the eventual total synthesis of the protein. It contained several original observations that would lead to the conclusion that the refolding of the ribonuclease molecule after full denaturation by reductive cleavage of its four disulfide bonds required that only one of the one hundred five possible pairings of eight sulfhydryl groups to form four disulfide linkages take place.
Extent:
3 pages
Date Issued:
12 April 1957
Creator:
Sela, Michael, White, Frederick H. (Frederick H. White), and Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Source:
Periodical. Sela, Michael, Frederick H. White, and Christian B. Anfinsen. "Reductive Cleavage of Disulfide Bridges in Ribonuclease." Science 125, 3250 (12 April 1957): 691-692. Article. 3 Images.. Science
Periodical:
Science
Publisher:
American Association for the Advancement of Science
Right Type:
Public Domain
Right Statement:
Courtesy of Science Magazine.
Profiles in Science ID:
KKBBLT
NLM ID:
101584571X182
Genre:
Articles
Language:
English
Format:
Text