[Revertant DNA data] (image 1)


Title:
[Revertant DNA data] (image 1)
Creator:
Varmus, Harold
Date:
[1978-1979]
Description:
Varmus made extensive use of gel electrophoresis in his study of the genetics of retroviruses, in this case to examine the integration of proviruses (the DNA form of viral RNA) of Avian Sarcoma Virus into the DNA of host cells. He found that proviruses have sequences at the end of their DNA chains that are repeated many times, and that proviruses are integrated into cellular chromosomes at many different sites. These findings helped explain how ASV transforms normal cells into cancer cells.. The ten lanes shown in this figure were formed when electrically charged (ionic) DNA fragments, which had been dissolved in a solvent and spread on an agarose gel as a support medium, migrate across an electric field and are separated according to the speed of their migration as well as according to changes they undergo during their migration.
Original Repository:
University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Location:
Box: 6. Folder: 16
Rights:
Reproduced with permission of the Regents of the University of California.
Genre:
Photographic prints
Subject:
DNA
Format:
Still Image
Extent:
1 pages
Relation:
[Revertant DNA data] (image 2), 1978
[Revertant DNA data] (image 3), 1978
Legacy Source Citation:
Original Repository. University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers. 12290
Legacy ID:
MVBBHP
NLM ID:
101584926X111
Profiles Collection:
The Harold Varmus Papers
Story Section:
Retroviruses and the Genetic Origins of Cancer, 1970-1993