Annealing cDNA3' and cDNA5' to Linear ASV DNA


Title:
Annealing cDNA3' and cDNA5' to Linear ASV DNA
Creator:
UCSF
Date:
[1978]
Description:
In 1976, Harold Varmus and Michael Bishop reported their pathbreaking discovery that a nucleotide sequence--the four letters of the DNA alphabet--of single-stranded, radioactive DNA from the normal cells of various species of birds (cDNA) could "anneal," or associate, with the cancer-causing gene, or oncogene, in Avian sarcoma virus (ASV) to form a double-stranded molecule. Their discovery suggested that normal, non-cancerous cells contain genes--proto-oncogenes, as Varmus and Bishop called them--that might mutate and cause cancer. The ultimate cause of cancer, the two scientists suggested, was to be found within our own genes. This slide provided a schematic of the annealing process.
Original Repository:
University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Location:
Box: 7. Folder: 5
Rights:
Reproduced with permission of the Regents of the University of California.
Genre:
Slides (photographs)
Charts (graphic documents)
Subject:
Avian Sarcoma Viruses and DNA
Format:
Still Image
Extent:
1 pages
Language:
English
Legacy Source Citation:
Original Repository. University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers. 12290
Legacy ID:
MVBBJQ
NLM ID:
101584926X132
Profiles Collection:
The Harold Varmus Papers
Story Section:
Retroviruses and the Genetic Origins of Cancer, 1970-1993