Title:

Annealing cDNA3' and cDNA5' to Linear ASV DNA

Creator:

UCSF

Date:

[1978]

Description:

In 1976, Harold Varmus and Michael Bishop reported their pathbreaking discovery that a nucleotide sequence--the four letters of the DNA alphabet--of single-stranded, radioactive DNA from the normal cells of various species of birds (cDNA) could "anneal," or associate, with the cancer-causing gene, or oncogene, in Avian sarcoma virus (ASV) to form a double-stranded molecule. Their discovery suggested that normal, non-cancerous cells contain genes--proto-oncogenes, as Varmus and Bishop called them--that might mutate and cause cancer. The ultimate cause of cancer, the two scientists suggested, was to be found within our own genes. This slide provided a schematic of the annealing process.

Original Repository:

University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers

Location:

Box: 7. Folder: 5

Rights:

Reproduced with permission of the Regents of the University of California.

Genre:

Slides (photographs)
Charts (graphic documents)

Subject:

Avian Sarcoma Viruses and DNA

Format:

Still Image

Extent:

1 pages

Language:

English

Legacy Source Citation:

Original Repository. University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers. 12290

Legacy ID:

MVBBJQ

NLM ID:

101584926X132

Profiles Collection:

The Harold Varmus Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584926X132

Story Section:

Retroviruses and the Genetic Origins of Cancer, 1970-1993