1. Three Decades of Wnts: A Personal Perspective on How a Scientific Field Developed

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2. Memorandum from Harold Varmus to the Grand Challenges in Global Health Scientific Advisory Board

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3. Letter from Harold Varmus to U.S. Senator Dick Durbin

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4. The New Era in Cancer Research

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5. Interim progress report of the Public Library of Science

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6. Is Science Under Siege?

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7. KRAS Mutations and Primary Resistance of Lung Adencarcinomas to Gefitnib or Erlotinib

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8. PLoS Pronunciation and Usage Key

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9. Grand Challenges in Global Health

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10. Minutes of the First Meeting of the PLoS Board of Directors

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