Title:

Effect of L-DOPA treatment on brain metabolism in the monkey

Creator:

National Institute of Mental Health (U.S.)

Date:

[ca. 1985]

Description:

Sokoloff's group used the deoxyglucose method to study many brain phenomena, including the effects of various drugs on cerebral metabolism. A series of studies in the mid-1980s explored the effects of l-dopa in the brains of monkeys with parkinsonism induced by MPTP. This is one of the slides used for presentations. It's a color-coded autoradiograph of a coronal section. It shows clearly that l-dopa increases metabolism in the brains of monkeys with induced parkinsonism, though not much in normal brains. See, e.g., LG Porrino, et al., "Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by 1-methyl-phenyl-1,2,3,6-tetrohydropyridine (MPTP) in the primate," Life Sciences 40 (1987): 1657-1664.

Location:

Box: 141. Folder: 10

Rights:

Public Domain

Genre:

Slides (photographs)

Format:

Still Image

Extent:

1 pages

Legacy ID:

NLBBGC

NLM ID:

101743402X85

Profiles Collection:

The Louis Sokoloff Papers

Shareable Link:

https://profiles.nlm.nih.gov/101743402X85

Story Section:

Positron Emission Tomography Scanning and Beyond, 1979-2004