Title:

A Nonhereditary, Host-Induced Variation of Bacterial Viruses

Creator:

Human, Mary L.
Luria, S. E. (Salvador Edward), 1912-1991

Date:

October 1952

Description:

In this article, Luria reported that some bacteria, when infected with phage, would modify the phage in such a way so that it cannot reproduce in that particular bacteria type. However, the variation gives the phage the ability to infect a different bacterial species, in this instance Shigella. This is the first instance of the phenomenon of restriction and modification that would soon after be explained by the discovery of restriction enzymes in bacteria. Luria's work with Human, which described bacterial restriction-modification systems, eventually led to the discovery of restriction enzymes.

Periodical:

Journal of Bacteriology

Publisher:

American Society for Microbiology

Rights:

Reproduced with permission of the American Society for Microbiology. and Reproduced with permission of the American Philosophical Society.

Genre:

Articles

Subject:

Bacteriophages and Viruses

Format:

Text

Extent:

13 pages

Language:

English

Legacy Source Citation:

Periodical. Luria, Salvador E., and Mary L. Human. "A Nonhereditary, Host-Induced Variation of Bacterial Viruses." Journal of Bacteriology 64, 4 (October 1952): 557-569. Article. 13 Images.. Journal of Bacteriology

Legacy ID:

QLBBBM

NLM ID:

101584611X10

Profiles Collection:

The Salvador E. Luria Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584611X10

Story Section:

Biographical Information