Letter from H. Gobind Khorana to Francis Crick

Title:
Letter from H. Gobind Khorana to Francis Crick
Description:
In his letter Khorana reported progress in his ongoing effort to synthesize in the laboratory a gene that codes for the transfer RNA of the amino acid tyrosine. In particular, he described work on the synthesis of the promoter sequence, a segment of DNA, usually located before a gene coding region in the base sequence, which acts as a controlling element in the expression of that gene, for example by regulating the beginning and the speed of transcription from DNA to RNA. Khorana also discussed the terminator sequence, which signals the end of the polypeptide chain in protein synthesis. He detailed the structure of the promoter and terminator sequences in schematic drawings attached to his letter.
Extent:
6 pages
Date Created:
22 May 1974
Creator:
Khorana, Har Gobind, 1922-2011
Recipient:
Crick, Francis, 1916-2004
Source:
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Right Type:
Permission Granted - No Conditions
Right Statement:
Reproduced with permission of H. Gobind Khorana.
Subject:
Genetic Code and RNA
Profiles in Science ID:
SCBBMR
NLM ID:
101584582X179
Genre:
Letters (correspondence) and Diagrams
Language:
English
Format:
Text
Location:
Box: 12. Folder: PP/CRI/D/1/2/6