Letter from Aaron Klug to Francis Crick


Title:
Letter from Aaron Klug to Francis Crick
Creator:
Klug, Aaron
Recipient:
Crick, Francis, 1916-2004
Date:
28 September 1976
Description:
Klug here related results from his X-ray diffraction studies of chromatin, the name given to the chromosomal material when extracted from the nucleus of cells in higher organisms (eukaryotic cells). Chromatin consists of DNA and an equal weight of associated, basic proteins called histones that serve as structural scaffolding. Klug examined the structural organization of chromatin in order to gain an understanding of how DNA is folded into the tight structure seen in a chromosome, how genes are separated by function, and how their expression is controlled.. Nucleosomes, also mentioned in the letter, are distinct complexes of histone and DNA in eukaryotic cells (cells with clearly-defined nuclei). Under the electron microscope they appear as bead-like bodies on a string of DNA.. Klug won the 1982 Nobel Prize in chemistry "for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes," chromatin and nucleosomes in particular.. NOTE: The margins of the second page are cut off in the original photocopied document.
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Location:
Box: 23. Folder: PP/CRI/D/2/18
Rights:
Reproduced with permission of Aaron Klug.
Genre:
Letters (correspondence)
Subject:
Crystallography, X-Ray, Chromatin, and Nucleosomes
Format:
Text
Extent:
3 pages
Language:
English
Legacy Source Citation:
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/
Legacy ID:
SCBBPS
NLM ID:
101584582X220
Profiles Collection:
The Francis Crick Papers
Story Section:
Embryology and the Organization of DNA in Higher Organisms, 1966-1976