Mutagenesis by Acridines in Bacteriophage T4


Title:
Mutagenesis by Acridines in Bacteriophage T4
Creator:
Crick, Francis, 1916-2004
Date:
[ca. 1961]
Description:
In this lecture Crick provided an account of genetic experiments conducted with Leslie Barnett, Sydney Brenner, and Richard Watts-Tobin in 1961. In these experiments they used acridine mutants of viral DNA (mutants produced by chemicals of the acridine type, such as proflavin, which trigger additions to or deletions from the base sequence) in order to demonstrate that the genetic code was a three-letter code. They published their findings in a seminal article in Nature in December 1961, entitled "General Nature of the Genetic Code for Proteins."
Original Repository:
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Location:
Box: 32. Folder: PP/CRI/E/1/9/12
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine. and http://library.wellcome.ac.uk/
Genre:
Lecture notes
Subject:
Genetic Code
Format:
Text
Extent:
3 pages
Relation:
General Nature of the Genetic Code for Proteins, 1961
Language:
English
Legacy Source Citation:
Original Repository. Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers. 11646. URL. http://archives.wellcome.ac.uk/
Legacy ID:
SCBBCP
NLM ID:
101584582X23
Profiles Collection:
The Francis Crick Papers
Story Section:
Deciphering the Genetic Code, 1958-1966